LEUKADHERIN-1

LEUKADHERIN-1

Stock Code: 3574205
Manufacturer Part No: SML0886-5MG
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£136.78 (exc VAT) per 5MG
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Biochem/physiol Actions


Leukadherin-1 is an agonist of complement receptor-3 (CR3) and exhibits anti-inflammatory activity. It is an allosteric agonist that activates integrin by binding to a different site from the ligand binding. Leukadherin-1 plays an important role in the margination and adhesion of neutrophils to the endothelial lining of the blood vessels.


Leukadherin-1 is an agonist of integrin CD11b/CD18 that can increase the extent of CD11b/CD18-dependent cell adhesion of transfected cells and of primary human and mouse neutrophils. Also, Leukadherin-1 decreases leukocyte recruitment and reduced arterial narrowing after injury in rats.


Packaging


5, 25 mg in glass bottle

Colour, yellow to orange to brown
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
SolubilityDMSO: 3 mg/mL, clear (warmed)
Formpowder
Assay≥98% (HPLC)

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