KU-0060648 >=98% (HPLC)

KU-0060648 >=98% (HPLC)

Stock Code: 3574668
Manufacturer Part No: SML1257-25MG
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£800.89 (exc VAT) per 25MG
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Biochem/physiol Actions


KU-0060648 is a very potent dual inhibitor of DNA-PK and PI3K. The IC50 values for inhibition of DNA-PK in MCF7 and SW620 cells are 19 and 170 nM, respectively. The compound KU-0060648 inhibits MCF7 PI3K activity with an IC50 of 39 nM, but is inactive against PI3K in SW620, suggesting a cell-dependent mechanism of inhibition. KU-0060648 increases sensitivity to DNA damaging cytotoxic drugs such as etoposide and doxorubicin in tumor cell lines expressing DNA-PK. KU-0060648 stimulates Cas9 (CRISPR associated protein 9) mediated genome editing by enhancing the rate of homology directed-repair (HDR) and decreasing the rate of NHEJ (non-homologous end-joining).


KU-0060648 is observed to inhibit proliferation and initiate apoptosis in hepatocellular carcinoma. KU-0060648 is useful in chemotherapy as it increases the efficiency of double stranded breaks initiated by anticancer drugs.


Packaging


5, 25 mg in glass bottle

Colourwhite to light brown
Quality Level100
InChI keyAATCBLYHOUOCTO-UHFFFAOYSA-N
InChI1S/C33H34N4O4S/c1-2-35-12-14-36(15-13-35)21-29(39)34-26-11-10-23(33-31(26)25-6-3-4-9-28(25)42-33)22-7-5-8-24-27(38)20-30(41-32(22)24)37-16-18-40-19-17-37/h3-11
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 1 mg/mL, clear (warmed)
Formpowder
Assay≥98% (HPLC)

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