KRIBB11 TRIFLUOROACETATE SALT >=98% (HP
Biochem/physiol Actions
KRIBB11 is an inhibitor of the transcription factor Heat Shock Factor 1 (HSF1) with an IC50 value of 1.2 µM. KRIBB11 blocks induction of HSF1 downstream target proteins such as HSP27 and HSP70 by impairing the recruitment of Positive Transcription Elongation Factor b (P-TEFb) to the HSF1 transcriptional complex, preventing HSF1-mediated gene expression KRIBB11 inhibits tumor growth in vivo and acts synergistically to increase apoptosis in cancer cells treated with the HSP90 inhibitors Geldanamycin and 17-AAG.
KRIBB11 is capable of preventing the proliferation of cancer cells. It has the ability to stimulate apoptosis and can arrest the cell cycle at G2/M phase.
Packaging
5, 25 mg in glass bottle
| Colour | yellow to orange |
|---|---|
| Quality Level | 100 |
| InChI key | DNBQMABUWGNHGB-UHFFFAOYSA-N |
| InChI | 1S/C13H12N6O2.C2HF3O2/c1-14-12-5-4-11(19(20)21)13(17-12)16-9-2-3-10-8(6-9)7-15-18-10;3-2(4,5)1(6)7/h2-7H,1H3,(H,15,18)(H2,14,16,17);(H,6,7) |
| Manufacturer | SIGMA-ALDRICH |
| Solubility | DMSO: 20 mg/mL, clear |
| Form | powder |
| Assay | ≥98% (HPLC) |
There are no downloads for this product.
