IRAK-1/4 Inhibitor I, >=98% (HPLC), solid

IRAK-1/4 Inhibitor I, >=98% (HPLC), solid

Stock Code: 3573407
Manufacturer Part No: I5409-5MG
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£253.50 (exc VAT) per 5MG
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Application


IRAK-1/4 inhibitor I has been used in various studies to inhibit IRAK1 in hepatoma cell lines and head and neck squamous cell carcinoma (HNSCC) cell lines.


Biochem/physiol Actions


IRAK-1/4 Inhibitor I is a novel benzimidazole that is a potent inhibitor of interleukin-1 receptor-associated kinases 1/4 (IRAK 1/4). IC50 values were 300 nM and 200 nM for IRAK-1 and -4, respectively, and >10,000 nM for a panel of 27 other kinases tested.


IRAK1 overexpression leads to the development of head and neck squamous cell carcinoma (HNSCC). Therefore, IRAK-1/4 inhibitor I might be a potential therapeutic for HNSCC tumors. Various experimental studies states that IRAK-1/4 inhibitor might have a potential to exhibitinhibitory effects on the nuclear factor (NF)-?B signaling pathway.


Packaging


5, 25 mg in glass bottle

Colouroff-white to light yellow
Quality Level100
InChI keyQTCFYQHZJIIHBS-UHFFFAOYSA-N
InChI1S/C20H21N5O4/c26-19(15-4-3-5-16(14-15)25(27)28)22-20-21-17-6-1-2-7-18(17)24(20)9-8-23-10-12-29-13-11-23/h1-7,14H,8-13H2,(H,21,22,26)
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: ≥5 mg/mL
Formsolid
Assay≥98% (HPLC)

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