IMATINIB MESYLATE

IMATINIB MESYLATE

Stock Code: 3574374
Manufacturer Part No: SML1027-100MG
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Application


Imatinib mesylate (IM) has been used:in sulforhodamine B cell viability assay to study its effect on CD34+ or CD38- and CD34+ or CD38+ cellsas an abelson1 (ABL1) kinase inhibitorin circular dichroism analysis to study the effect of IM binding on the secondary structure of the human transferrins


Biochem/physiol Actions


Imatinib mesylate is a tyrosine kinase inhibitor with antineoplastic activity. Imatinib is a potent inhibitor of the Bcr-Abl kinase encoded by the bcr-abl oncogene as well as receptor tyrosine kinases encoded by c-kit and platelet-derived growth factor receptor (PDGFR) oncogenes. Imatinib mesylate inhibition of Bcr-Abl tyrosine kinase created by the Philadelphia chromosome abnormality found in CML decreases proliferation and enhances apoptosis in leukemias CML and ALL. Inhibition of c-kit tyrosine activity inhibits mast-cell and cellular proliferation in those diseases overexpressing c-kit such as gastrointestinal stromal tumor (GIST).


Features and Benefits


This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.


Other Notes


Imatinib has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the Imatinib probe summary on the Chemical Probes Portal website.


Packaging


10, 100 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyYLMAHDNUQAMNNX-UHFFFAOYSA-N
InChI1S/C29H31N7O.CH4O3S/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36;1-5(2,3)4/h3-13,18-19
ManufacturerSIGMA-ALDRICH
SolubilityH2O: 10 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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