IKK-16 DIHYDROCHLORIDE >=98% HPLC

IKK-16 DIHYDROCHLORIDE >=98% HPLC

Stock Code: 3574514
Manufacturer Part No: SML1138-25MG
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£686.68 (exc VAT) per 25MG
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Application


IKK-16 dihydrochloride has been used as an nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor kinase inhibitor (I?B) in B220+ CKO or CreWT naive B cells. It has also been used as a nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?B inhibitor) in poly(I:C) transfection-induced retinoic acid-inducible gene (RIG-I), melanoma differentiation-associated gene 5 (MDA-5), and caspase-11 expressing mouse embryonic fibroblasts (MEFs).


Biochem/physiol Actions


IKK-16 is a selective inhibitor of IKB kinase (IKK), part of the upstream NF-KB signal transduction cascade involved in the cellular response to inflammation. IKK-16 has IC50 values of 40, 70 and 200 nM for IKKβ (IKK-2), IKK complex and IKKα (IKK-1) respectively. In a mouse sepsis model, IKK-16 reduced the multiple organ dysfunction, showing an antiinflammatory and endothelial protective effect likely mediated by inhibition of inflammation through NF-KB. IKK-16 has also been found to have some activity as an inhibitor of protein kinase D (PKD) and of multidrug resistance protein 1 (MDR1, ABCB1).


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyYJGZKHHCMOHIFA-UHFFFAOYSA-N
InChI1S/C28H29N5OS.CH4/c34-27(33-17-12-23(13-18-33)32-15-3-4-16-32)20-7-9-22(10-8-20)30-28-29-14-11-24(31-28)26-19-21-5-1-2-6-25(21)35-26;/h1-2,5-11,14,19,23H,3-4,1
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 20 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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