Hydroxyfasudil hydrochloride hydrate, >=98% (HPLC), solid
Application
Hydroxyfasudil hydrochloride hydrate has been used as a ROCK inhibitor to study the role of different signaling pathways in the chemokines CCL19 and CCL21, the CCR7 ligands mediated effects on migratory and prosurvival, in CLL cells.
Biochem/physiol Actions
Rho-kinase inhibitor.
Hydroxyfasudil possessantispastic action. It is an active metabolite of fasudil. Hydroxyfasudil might enhance the dynamics of blood flow and prevent damage caused by neutrophils.
Packaging
5, 25 mg in glass bottle
| Colour | white |
|---|---|
| Quality Level | 100 |
| InChI key | XWWFOUVDVJGNNG-UHFFFAOYSA-N |
| InChI | 1S/C14H17N3O3S.ClH/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17;/h1,3-5,7,15H,2,6,8-10H2,(H,16,18);1H |
| Manufacturer | SIGMA-ALDRICH |
| Composition | The two peaks show the equilibrim between the two tautomers |
| Form | solid |
| Assay | ≥98% (HPLC) |
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