GIMERACIL

Descriptions

Biochem/physiol Actions

Gimeracil (5-chloro-2, 4-dihydroxypyridine) is an orally active inhibitor against dihydropyrimidine dehydrogenase (DPYD), which degrades pyrimidine and the chemotherapeutic drug 5-fluorouracil (5FU). Gimeracil is shown to exhibit cancer-radiosensitizing efficacy in cultures in vitro (1 mM) and in mice in vivo (2.5-25 mg/kg, p.o.) in a DPYD-dependent manner via partial suppression of DNA repair by homologous recombination (HR).

Specifications

Colour	white to brown
InChI key	ZPLQIPFOCGIIHV-UHFFFAOYSA-N
InChI	1S/C5H4ClNO2/c6-3-2-7-5(9)1-4(3)8/h1-2H,(H2,7,8,9)
Manufacturer	SIGMA-ALDRICH
Storage Temp.	−20°C
Solubility	DMSO: 2 mg/mL, clear
Form	powder
Assay	≥98% (HPLC)