FURAMIDINE DIHYDROCHLORIDE

FURAMIDINE DIHYDROCHLORIDE

Stock Code: 3575086
Manufacturer Part No: SML1559-25MG
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£571.07 (exc VAT) per 25MG
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Biochem/physiol Actions


Furamidine (DB75) binds to strings of AT base pair sequences in DNA′s minor groove. Furamidine was originally developed as an anti-parasitic compound for a variety of diseases including Chagas′ disease. Furamidine targets AT rich sequences in trypanosome kinetoplast minicircle DNA (kDNA), resulting in subsequent destruction of the kinetoplast and cell death. Furamidine has also been found to inihbit tyrosyl-DNA phosphodiesterase (Tdp1) and act as a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4µM.


General description


Furamidine dihydrochloride is an analog of the aromatic drug pentamidine and a substrate of the organic cation transporter 1 (OCT1). A number of prodrugs of furamidine dihydrochloride are being synthesised and are in clinical trial stages.


Packaging


5 mg in glass bottle

Colourwhite to beige
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
SolubilityH2O: 1 mg/mL, clear (warmed)
Formpowder
Assay≥98% (HPLC)

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