FQI1, >=98% (HPLC)
Biochem/physiol Actions
FQI1 inhibits the DNA-binding activity of LSF, a ubiquitous transcription factor that is up regulated in many hepatocellular carcinomas (HCC). FQI1 inhibits LSF-dependent luciferase reporter expression, blocks proliferation in cancer cell lines, and induces apoptosis in liver cancer cells but is not toxic to primary hepatocytes. FQI1 also inhibits tumor growth in a mouse HCC xenograft model.
Packaging
5, 25 mg in glass bottle
| Colour | white to beige |
|---|---|
| Quality Level | 100 |
| InChI key | YKSYGLXHLSPWLB-UHFFFAOYSA-N |
| InChI | 1S/C18H17NO4/c1-2-21-15-6-4-3-5-11(15)12-8-18(20)19-14-9-17-16(7-13(12)14)22-10-23-17/h3-7,9,12H,2,8,10H2,1H3,(H,19,20) |
| Manufacturer | SIGMA-ALDRICH |
| Solubility | DMSO: 10 mg/mL (clear solution) |
| Form | powder |
| Assay | ≥98% (HPLC) |
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