Exo 1, >=98% (HPLC), solid
Application
Exo 1 has been used as a component of the BRB80 buffer to study coat protein 1 (COPI)-mediated membrane trafficking. It has also been used as a Golgi inhibitor to study its effects on the longinterspersednuclearelement-1 (L1) retrotransposition.
Biochem/physiol Actions
Reversible inhibitor of exocytosis; Golgi ARF 1 (ADP-Ribosylation Factor) GTPase activator.
Exo 1 is a cell-permeable methylanthranilate analog that promotes the release of adenosine diphosphate (ADP)-ribosylation factor (ARF) 1 from Golgi membranes. It also inhibits the membrane trafficking between the endoplasmic reticulum (ER) and the Golgi bodies.
Packaging
5, 25 mg in glass bottle
| Quality Level | 100 |
|---|---|
| InChI key | KIAPWMKFHIKQOZ-UHFFFAOYSA-N |
| InChI | 1S/C15H12FNO3/c1-20-15(19)12-4-2-3-5-13(12)17-14(18)10-6-8-11(16)9-7-10/h2-9H,1H3,(H,17,18) |
| Manufacturer | SIGMA-ALDRICH |
| Solubility | DMSO: soluble 19 mg/mL |
| Form | solid |
| Assay | ≥98% (HPLC) |
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