Dynasore hydrate,
Application
Dynasore hydrate has been used:for priming fetal mesenchymal stem/stromal cells (fMSC)in confocal microscopyin wound healing/scratch and tube-formation assayto analyse its effects on Coxsackievirus A9 (CAV9) infectionto inhibit clathrin-mediated endocytosis and caveolin-mediated endocytosisin live imaging of cells
Biochem/physiol Actions
Dynasore is a cell-permeable, reversible noncompetitive dynamin 1 and dynamin 2 GTPase activity inhibitor.
Features and Benefits
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General description
Dynasore is a small molecule GTPase inhibitor that targets dynamin-1, dynamin-2 and Drp1 (mitochondrial). Dynasore blocks dynamin-dependent endocytosis, scission of endocytic vesicles. Dynosore is profibrotic, induces PAI-1 in pleural mesothelial cells, and may be an effective pleurodesing (pleurodesis) agent. Dynasor blocks human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization. Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.
Packaging
5, 25 mg in glass bottle
| Colour | off-white |
|---|---|
| Quality Level | 100 |
| InChI key | FKWZHQSDBMSHTN-ZIOFAICLSA-N |
| InChI | 1S/C18H14N2O4.H2O/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22;/h1-10,21-23H,(H,20,24);1H2/b19-10+; |
| Manufacturer | SIGMA-ALDRICH |
| Solubility | H2O: insoluble, DMSO: ≥10 mg/mL |
| Form | powder |
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