Dynasore hydrate,

Dynasore hydrate,

Stock Code: 3573340
Manufacturer Part No: D7693-5MG
Order Now for 21 day delivery
£153.21 (exc VAT) per 5MG
Quantity: - +

Application


Dynasore hydrate has been used:for priming fetal mesenchymal stem/stromal cells (fMSC)in confocal microscopyin wound healing/scratch and tube-formation assayto analyse its effects on Coxsackievirus A9 (CAV9) infectionto inhibit clathrin-mediated endocytosis and caveolin-mediated endocytosisin live imaging of cells


Biochem/physiol Actions


Dynasore is a cell-permeable, reversible noncompetitive dynamin 1 and dynamin 2 GTPase activity inhibitor.


Features and Benefits


This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.


General description


Dynasore is a small molecule GTPase inhibitor that targets dynamin-1, dynamin-2 and Drp1 (mitochondrial). Dynasore blocks dynamin-dependent endocytosis, scission of endocytic vesicles. Dynosore is profibrotic, induces PAI-1 in pleural mesothelial cells, and may be an effective pleurodesing (pleurodesis) agent. Dynasor blocks human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization. Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.


Packaging


5, 25 mg in glass bottle

Colouroff-white
Quality Level100
InChI keyFKWZHQSDBMSHTN-ZIOFAICLSA-N
InChI1S/C18H14N2O4.H2O/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22;/h1-10,21-23H,(H,20,24);1H2/b19-10+;
ManufacturerSIGMA-ALDRICH
SolubilityH2O: insoluble, DMSO: ≥10 mg/mL
Formpowder

There are no downloads for this product.