DROTAVERINE HYDROCHLORIDE

Descriptions

Biochem/physiol Actions

Drotaverine (Drotaverin) is an isoquinoline-based PDE4-selective phosphodiesterase (PDE) inhibitor and an L-type voltage-dependent (voltage-operated) calcium channel (L-VDCC or L-VOCC) blocker that exhibits in vivo antispasmodic efficacy without anticholinergic effects.

It is a benzylisoquinoline derivative. Drotaverine acts as a smooth muscle relaxant.

Specifications

Colour	white to beige
Quality Level	100
InChI key	JBFLYOLJRKJYNV-MASIZSFYSA-N
InChI	1S/C24H31NO4.ClH/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20;/h9-10,13-16,25H,5-8,11-12H2,1-4H3;1H/b20-13-;
Manufacturer	SIGMA-ALDRICH
Solubility	DMSO: 2 mg/mL, clear (warmed)
Form	powder
Assay	≥95% (HPLC)