Biochem/physiol Actions
DIBA-1 (2,2′-dithiobisbenzamide-1) is a disulfide that interacts with zinc fingers as a zinc ejector. It has been shown to interact with many zinc finger containing proteins, including HIV-1 nucleocapsid and the estrogen receptor. DIBA-1 has been studied as a candidate for the treatment of AIDS and also breast cancer. In one study DIBA restored tamoxifen sensitivity in resistant breast cancer.
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| Colour | white to light brown |
|---|---|
| Quality Level | 100 |
| InChI key | FVGJPHFQQMQGFQ-UHFFFAOYSA-N |
| InChI | 1S/C26H22N4O6S4/c27-39(33,34)19-13-9-17(10-14-19)29-25(31)21-5-1-3-7-23(21)37-38-24-8-4-2-6-22(24)26(32)30-18-11-15-20(16-12-18)40(28,35)36/h1-16H,(H,29,31)(H, |
| Manufacturer | SIGMA-ALDRICH |
| Form | powder |
| Assay | ≥97% (NMR) |
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