CLEMIZOLE HYDROCHLORIDE

CLEMIZOLE HYDROCHLORIDE

Stock Code: 3574920
Manufacturer Part No: SML1447-25MG
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£466.61 (exc VAT) per 25MG
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Biochem/physiol Actions


Clemizole is a potent and preferring inhibitor of TRPC5 that efficiently blocks heterologously expressed homomeric TRPC5 channels as well as heteromeric TRPC1:TRPC5 channels. Clemizole is a potent and selective H1 histamine receptor antagonist. Clemizole inhibited binding of HCV RNA by NS4B inhibit HCV RNA replication in cell culture.


Clemizole is an antihistamine and an inhibitor of NS4B (nonstructural protein 4B) RNA of HCV (hepatitis C virus). Studies in Scn1? (sodium channel, voltage-gated, type I, ?) Zebrafish mutant show that this drug has the potential as a therapeutic agent in Dravet Syndrome treatment.


General description


Clemizole is a potent anti-allergic drug.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyDNFMJYXRIMLMBZ-UHFFFAOYSA-N
InChI1S/C19H20ClN3.ClH/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22;/h1-2,5-10H,3-4,11-14H2;1H
ManufacturerSIGMA-ALDRICH
SolubilityH2O: 2 mg/mL, clear (warmed)
Formpowder
Assay≥98% (HPLC)

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