CGP 57380, >=98% (HPLC)

CGP 57380, >=98% (HPLC)

Stock Code: 3573299
Manufacturer Part No: C0993-5MG
Order Now for 7 day delivery
£298.07 (exc VAT) per 5MG
Quantity: - +

Application


CGP 57380 has been used: as a mitogen-activated protein kinase-interacting kinase 1 (MNK1) inhibitor to investigate the role of Mnk1 on eukaryotic translation initiation factor 4F (eIF4F) assembly and Newcastle disease virus (NDV) replication in HeLa cellsas an MNK1 inhibitor to block eIF4 complex to evaluate the contribution of interferon (IFN-?) translation during m157- transgenic (Tg) stimulationas a ?-catenin nuclear translocation inhibitor to analyze its effects on cytoplasmic and nuclear fractions of cells


Biochem/physiol Actions


CGP 57380 is a ?-catenin nuclear translocation inhibitor, which prevents the proliferation of severalcancers. It enhances radiation-induced apoptosis in nasopharyngeal carcinoma (NPC). CGP 57380 upregulates ?-catenin in the cytoplasm and inhibits epithelial-mesenchymal transition (EMT).


CGP 57380 is a cell-permeable selective inhibitor of mitogen-activated protein kinase-interacting kinase 1 (MNK1).


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyUQPMANVRZYYQMD-UHFFFAOYSA-N
InChI1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
ManufacturerSIGMA-ALDRICH
SolubilityH2O: ﹤2 mg/mL, DMSO: 10 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

There are no downloads for this product.