CD40-TRAF6 SIGNALING INHIBITOR

CD40-TRAF6 SIGNALING INHIBITOR

Stock Code: 3574546
Manufacturer Part No: SML1160-25MG
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£438.75 (exc VAT) per 25MG
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Application


CD40-TRAF6 signaling inhibitor has been used to treat human embryonic kidney (HEK)-293T cellsto test its inhibitory effect on the tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6) leading to subsequent abrogation of (P2RY6)-dependent nuclear factor kappa B (NF-?B).


Biochem/physiol Actions


CD40-TRAF6 signaling inhibitor is a small molecule that binds to TRAF6, blocking interactions with CD40. The compound inhibits CD40-induced production of IL-1b and IL-6 in primary macrophages. The compound reduces insulin resistance and adipose tissue inflammation in a mouse diet induced obesity model.


CD40-TRAF6 (cluster of differentiation 40-TNF receptor associated factor) signaling is recognized as an effective target in treating vascular disease.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyWIFPLULEUNBSTE-GZTJUZNOSA-N
InChI1S/C16H15NO/c1-12-8-9-13(2)15(10-12)17-11-16(18)14-6-4-3-5-7-14/h3-11H,1-2H3/b17-11+
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 20 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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