CBIQ, >=98% (HPLC), solid

CBIQ, >=98% (HPLC), solid

Stock Code: 3573321
Manufacturer Part No: C6617-5MG
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£168.54 (exc VAT) per 5MG
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Biochem/physiol Actions


CBIQ is an activator of the cystic fibrosis transmembrane conductance regulator (CFTR) and the intermediate-conductance calcium-sensitive K+ channel (KCNN4). CBIQ is a novel tool for a new ion channel; first activator of δF508 CFTR, the mutant form of CFTR chloride channel present in 75% of cystic fibrosis patients. Other benzoquinolines act at the normal CFTR but not at δF508 CFTR. CBIQ also activates KCNN4, which hyperpolarizes airway epithelial cells to promote anion flux, a further benefit in cystic fibrosis.


Features and Benefits


This compound is featured on the Chloride Channels and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.


Packaging


5, 25 mg in glass bottle

Colouroff-white
Quality Level100
InChI keySHQLTRRYZVBEMR-UHFFFAOYSA-N
InChI1S/C13H8ClN/c14-13-12-6-5-9-3-1-2-4-10(9)11(12)7-8-15-13/h1-8H
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 15 mg/mL
Formsolid
Assay≥98% (HPLC)

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