C646, >=98% (HPLC)
Application
C646 was used to study the role of p300 in chronic neuropathic pain in rats with chronic constriction injury.
Biochem/physiol Actions
C646 is a competitive histone acetyltransferase (HAT) p300/CBP inhibitor with a Ki of 400 nM and is selective versus other acetyltransferases.
C646 is a potent, cell permeable and selective inhibitor of p300 and CBP (p300/CBP) histone acetyltransferases. Inhibition of p300/CBP by C646 affects the activity of a variety of transcriptional factors such as NF-?B, p53 and MyoD that are associated with physiology, disease processes, hippocampal synaptic plasticity, spatial memory and contextual fear.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Packaging
5, 25 mg in glass bottle
| Colour | red to brown |
|---|---|
| Quality Level | 100 |
| InChI key | HEKJYZZSCQBJGB-UNOMPAQXSA-N |
| InChI | 1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12- |
| Manufacturer | SIGMA-ALDRICH |
| Solubility | DMSO: >25 mg/mL |
| Form | powder |
| Assay | ≥98% (HPLC) |
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