Application
Bz-423 has been used as a mitochondrial inner membrane pore (MIMP) reagent to study its effect on oxygen consumption rate (OCR) and ATP synthesis in HepG2 cells.
Biochem/physiol Actions
Bz-423 stimulates mitochondrial inner membrane pore (MIMP) opening in isolated mitochondria.
Bz-423 is an inhibitor of mitochondrial F1F0 ATP synthase. It binds the oligomycin sensitivity conferring protein (OSCP) component of mitochondrial F1F0-ATPase, resulting in superoxide generation and apoptosis. BZ-423 was shown to block multidrug-resistant melanoma cells. In another study, Bz-423 selectively increased superoxide and induced the apoptosis of alloreactive T cells, which arrested established Graft versus Host Disease.
| Colour | white to beige |
|---|---|
| Quality Level | 100 |
| InChI key | IJEUIRDNQUQMFU-UHFFFAOYSA-N |
| InChI | 1S/C27H21ClN2O2/c1-30-25-13-10-21(28)16-23(25)26(19-8-11-22(31)12-9-19)29-24(27(30)32)15-17-6-7-18-4-2-3-5-20(18)14-17/h2-14,16,24,29H,15H2,1H3 |
| Manufacturer | SIGMA-ALDRICH |
| Solubility | DMSO: 2 mg/mL, clear |
| Form | powder |
| Assay | ≥98% (HPLC) |
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