BPV(HOPIC)
Application
bpV(HOpic) has been used in pharmacological perturbation of cell migration related signaling pathway.
Biochem/physiol Actions
bpV(OHpic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(HOpic) are 14 nM for PTEN compared to 4.9 µM for PTPβ and 25.3 µM for PTP-1β. bpV(HOpic) has been shown to enhance PI3K/Akt signaling that could prevent myocardium from ischemia-reperfusion injury.
Other Notes
Soluble in DMSO or water. NOTE: The product is not stable in water. Decomposition starts immediately after solubilization. Rate of decomposition is slower in dry DMSO.
Packaging
5, 25 mg in glass bottle
| Colour | faintly yellow to dark yellow |
|---|---|
| Quality Level | 100 |
| Manufacturer | SIGMA-ALDRICH |
| Storage Temp. | −20°C |
| Solubility | H2O: 20 mg/mL, clear |
| Form | powder |
| Assay | ≥90% V basis |
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