BOSENTAN HYDRATE

BOSENTAN HYDRATE

Stock Code: 3574681
Manufacturer Part No: SML1265-50MG
Order Now for 7 day delivery
Click Add to Quote for price and delivery
Quantity: - +

Application


Bosentan hydrate has been used in cell viability assay. It has also been used as a positive control for calcium transient analysis.


Biochem/physiol Actions


Bosentan is an endothelin receptor antagonist. Endothelin is a potent vasoconstrictor, making antagonists of clinical interest for the treatment of conditions associated with vasospasm, such as subarachnoid hemorrhage (SAH) and hypertension. Bosentan is a dual endothelin receptor antagonist effective in the treatment of pulmonary arterial hypertension (PAH), the first of the class to make it to market. Bosentan is an orally available, competitive antagonist of both the ETA and ETB receptor subtypes with a Ki of 4.7 nM for ETA and a Ki of 95 nM for ETB.


Bosentan is found to decrease deposition of collagen in the lungs, which has been observed in bleomycin-induced pulmonary fibrosis rat model.


Packaging


10, 50 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keySXTRWVVIEPWAKM-UHFFFAOYSA-N
InChI1S/C27H29N5O6S.H2O/c1-27(2,3)18-10-12-19(13-11-18)39(34,35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-14-7-15-29-24;/h5-15,33H,16-17H2,
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
SolubilityDMSO: 5 mg/mL, clear (warmed)
Formpowder
Assay≥98% (HPLC)

There are no downloads for this product.