BF-170 hydrochloride, >=98% (HPLC), solid

BF-170 hydrochloride, >=98% (HPLC), solid

Stock Code: 3573279
Manufacturer Part No: B4311-25MG
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£364.93 (exc VAT) per 25MG
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Biochem/physiol Actions


BF-170 is a new probe for neurofibrillary tangles (tau fibrils). It exhibits greater binding affinity to tau than to Aβ fibrils, EC50 = 221 nM vs. EC50 = 786 nM (Ki for Aβ > 5,000 nM). BF-170 demonstrates fast clearance from the brain; clearly visualizes neurofibrillary tangles, neuropil threads, and paired helical filament-type neuritis. BF-70 may become one of the candidate compounds for in vivo imaging of tau pathology associated with Alzheimer′s disease and is a useful tool in distinguishing among tau and Aβ fibrils specifically in AD.


Caution


Product is air sensitive, store under inert gas.


Packaging


5, 25 mg in glass bottle

Colourorange
Quality Level100
InChI keyUYYPMQOFLJHJAW-UHFFFAOYSA-N
InChI1S/C15H12N2.ClH/c16-13-8-5-12(6-9-13)15-10-7-11-3-1-2-4-14(11)17-15;/h1-10H,16H2;1H
ManufacturerSIGMA-ALDRICH
SolubilityH2O: 10 mg/mL
Formsolid
Assay≥98% (HPLC)

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