BEPRISTAT 2A HYDROCHLORIDE

BEPRISTAT 2A HYDROCHLORIDE

Stock Code: 3575562
Manufacturer Part No: SML1925-5MG
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£168.54 (exc VAT) per 5MG
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Biochem/physiol Actions


Bepristat 2a is a selective reversible inhibitor of protein disulfide isomerase (PDI), an enzyme in the endoplasmic reticulum that catalyzes disulfide bond breakage and reformation to catalyze protein folding. Unlike most PDI inhibitors, Bepristat 2a binds at the substrate-binding site, rather than the catalytic site. Bepristat 2a blocked PDI activity with an IC50 value of 1200 nM, while enhancing catalytic activity of remote PDI domains. PDI is up-regulated in several cancers, has been implicated in neurodegenerative processes, and plays an important role in thrombus formation. Bepristat 2a potently inhibited platelet aggregation and thrombus formation in vivo.

Colourwhite to beige
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
SolubilityH2O: 10 mg/mL, clear
Formpowder
Assay≥95% (HPLC)

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