AURORA-A INHIBITOR I

AURORA-A INHIBITOR I

Stock Code: 3574198
Manufacturer Part No: SML0882-5MG
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Application


Aurora-A Inhibitor I has been used to study its effect on cell viability of human megakaryoblastic cell line (SET-2) and human erythroleukemia cell line (HEL) by methylthiazoletetrazolium (MTT) assay.


Biochem/physiol Actions


Aurora-A Inhibitor I, also known as TC?S7010, stimulates G2/M cell cycle arrest and apoptosis in ARID1A ?/? cells.


Aurora-A Inhibitor I is a potent inhibitor of Aurora kinase A with an IC50 of 3.4 nM and 1000-fold selectivity for Aurora A over Aurora B (better than VX-680) and even higher for CDKs. Antiproliferative IC50 values were in the vicinity of 1 µM against the human colorectal cancer cell line HCT116.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
SolubilityDMSO: 10 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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