AubipyOMe is a potent inhibitor of tartrate resistant acid phosphatase (TRAP/ACP5), a metalloenzyme expressed in activated osteoclasts and in macrophages. AubipyOMe exhibited IC50 values of 1.3 µM for TRAP5a and 1.8 µM for TRAP5b and inhibited TRAP activity in murine macrophage and human lung tissue extracts.