ATRASENTAN HYDROCHLORIDE

ATRASENTAN HYDROCHLORIDE

Stock Code: 3575704
Manufacturer Part No: SML2020-5MG
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Biochem/physiol Actions


Atrasentan is a selective endothelin ETA receptor antagonist with an IC50 of 0.2 nM for ETA compared to 190 nM for ETB receptors. It blocks blocks endothelin induced cell proliferation, and has been investigated as a possible treatment for prostate cancer, and more recently for therapy for diabetic kidney disease.


General description


Atrasentan has also been used to treat cardiovascular disease.

Colourwhite to beige
InChI keyIJFUJIFSUKPWCZ-SQMFDTLJSA-N
InChI1S/C29H38N2O6.ClH/c1-4-6-14-30(15-7-5-2)26(32)18-31-17-23(21-10-13-24-25(16-21)37-19-36-24)27(29(33)34)28(31)20-8-11-22(35-3)12-9-20;/h8-13,16,23,27-28H,4-7,14
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 2 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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