ANAGRELIDE HYDROCHLORIDE

ANAGRELIDE HYDROCHLORIDE

Stock Code: 3574165
Manufacturer Part No: SML0846-10MG
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Biochem/physiol Actions


In human and animals, anagrelide has an inhibitory effect on platelet aggregation. Small doses of anagrelide can generate thrombocytopenia. Anagrelide is not advised during pregnancy. It is effectively used in the treatment of essential thrombocytosis.


Anagrelide is a phosphodiesterase inhibitor with antiplatelet activity.


Anagrelide is a phosphodiesterase inhibitor with antiplatelet activity (IC50 = 36 nM for inhibition of phosphodiesterase-III). Anagrelide inhibits the maturation of megakaryocytes into platelets, reducing both megakaryocyte hyperproliferation and differentiation. As a drug, anagrelide is antithrombocythemic used for the treatment of overproduction of blood platelets.


Features and Benefits


This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.


This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.


General description


Anagrelide belongs to the imidazo[2,1-b]quinazolin-2-one series of compounds.


Download the CofA, SDS and IFU specific to your product lot and formatFab fragments from polyclonal anti-fluorescein antibodies, conjugated to alkaline phosphatase.After immunization with fluorescein, the sheep IgG was purified by ion exchange chromatography and the specific IgG was isolated by immunosorption. The Fab fragments obtained by papain digestion were purified by gel filtration, conjugated with alkaline phosphatase, and stabilized in 50 mM triethanolamine buffer, 3 M NaCl, 1 mM MgCl2, 0.1 mM ZnCl2, 1% bovine serum albumin (w/v), pH 7.6.Clone: polyclonalIg class: sheep IgG, Fab fragments


Packaging


10, 50 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyTVWRQCIPWUCNMI-UHFFFAOYSA-N
InChI1S/C10H7Cl2N3O.ClH/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7;/h1-2H,3-4H2,(H,13,14,16);1H
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 1 mg/mL, clear (warmed)
Formpowder
Assay≥98% (HPLC)

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