AMTB hydrate, >=98% (HPLC)

AMTB hydrate, >=98% (HPLC)

Stock Code: 3574020
Manufacturer Part No: SML0103-25MG
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£487.50 (exc VAT) per 25MG
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Application


AMTB hydrate has been used as an inhibitor of transient receptor potential cation channel, subfamily melastatin, member 8 (TRPM8) in breast cancer cells and murine T cells.


Biochem/physiol Actions


AMTB is a 2-benzyloxy-benzoic acid amide derivative, which also inhibits voltage-gated sodium channels (Nav) and their isoforms.


AMTB is a TRPM8-selective antagonist with no cross reactivity to TRPV1 or 4. The pIC50 of icilin activation of TRPM8 is 6.23 i.v. administration of AMTB reduced the frequency of rhythmic contractions in volume-loaded bladder and inhibited blood pressure and visceromotor reflex responses to bladder distention.


Packaging


5, 25 mg in glass bottle

Colourwhite to tan
Quality Level100
InChI keyRTYVTAQFASBIDN-UHFFFAOYSA-N
InChI1S/C23H26N2O2S.ClH.H2O/c1-18-8-2-3-9-19(18)17-27-22-12-5-4-11-21(22)23(26)25(14-7-13-24)16-20-10-6-15-28-20;;/h2-6,8-12,15H,7,13-14,16-17,24H2,1H3;1H;1H2
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: ≥10 mg/mL
Formpowder
Assay≥98% (HPLC)

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