AMBRISENTAN

Descriptions

Biochem/physiol Actions

Ambrisentan is an endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension (PAH). It is 200-fold selective for the the ETA receptor subtype with a Ki of 1 nM for ETA and a Ki of 195 nM for ETB.

Specifications

Colour	white to beige
InChI key	OUJTZYPIHDYQMC-UHFFFAOYSA-N
InChI	1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)
Manufacturer	SIGMA-ALDRICH
Solubility	DMSO: 2 mg/mL, clear
Form	powder
Assay	≥98% (HPLC)