Alantolactone, >=98% (HPLC)

Alantolactone, >=98% (HPLC)

Stock Code: 3574070
Manufacturer Part No: SML0415-25MG
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£523.71 (exc VAT) per 25MG
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Application


Alantolactone has been used:in cell viability assayto examine the percentage of multicentrosomal mitosis in low and high passage human embryonic stem cells (hESC)in assessment of degranulation


Biochem/physiol Actions


Alantolactone is a sesquiterpene lactone disrupts the Cripto-1/ActRII complexes, resulting in an induction of activin/SMAD3 signaling. Alantolactone inhibits proliferation in cancer cells with no affect on normal cells.


General description


Alantolactone is a compound produced by Inula helenium. Alantolactone has antibacterial, antifungal, anti-inflammatory and anticancer properties. It suppresses signal transducer and activator of transcription 3 (STAT3) activation in liver and breast cancer cells. Alantolactone induces apoptosis in A549 lung cancer cells.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyPXOYOCNNSUAQNS-AGNJHWRGSA-N
InChI1S/C15H20O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h7,9,11,13H,2,4-6,8H2,1,3H3/t9-,11+,13+,15+/m0/s1
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 15 mg/mL (clear solution)
Formpowder
Assay≥98% (HPLC)

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