AG-205, >=98% (HPLC)

AG-205, >=98% (HPLC)

Stock Code: 3573241
Manufacturer Part No: A1487-5MG
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Application


AG-205 has been used to investigate the neuroprotective effects of norgestrel on stressed photoreceptors. It has also been used to study the effect of blocking progesterone receptor membrane component 1 in 661W cells.


Biochem/physiol Actions


Pgrmc1 is a cytochrome associated protein. It is found to be upregulated in several cancer types such as breast, lung and gastric cancer. Pgrmc1 regulates the epidermal growth factor signaling.


AG-205 is a Pgrmc1 (progesterone receptor membrane component 1) inhibitor. AG-205 alters the spectroscopic properties of the Pgrmc1-heme complex. AG-205 inhibits cancer cell viability and cancer cell progression. acting preferentially on Pgrmc1-expressing cells.


Features and Benefits


This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.


Packaging


5, 25 mg in glass bottle

Colouroff-white to brown
Quality Level100
InChI keyGJNBAISSZRNGTM-UYAOXDASSA-N
InChI1S/C22H23ClN6OS/c1-14-3-8-19-17(11-14)18-12-27(2)10-9-20(18)28(19)21(30)13-31-22-24-25-26-29(22)16-6-4-15(23)5-7-16/h3-8,11,18,20H,9-10,12-13H2,1-2H3/t18-,20-/
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: >9 mg/mL (warmed)
Formpowder
Assay≥98% (HPLC)

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