AF-DX 116, >=98% (HPLC)

AF-DX 116, >=98% (HPLC)

Stock Code: 3574089
Manufacturer Part No: SML0435-5MG
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£139.29 (exc VAT) per 5MG
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Application


AF-DX 116 has been used as an M2 muscarinic acetylcholine receptor (M2AChR) selective antagonist to study the influence of M2AChR in the regulation of both basal and carbachol-stimulated long-term potentiation at the dentate gyrus (DG-LTP) and pro-nerve growth factor (proNGF) secretion in hippocampal cells of young diabetic rats.


Biochem/physiol Actions


AF-DX 116 is a selective M2 muscarinic acetylcholine receptor antagonist.


AF-DX 116 raises blood pressure and heart rate in a rat model of hypotension induced by repeated cold stress. Thus, it may be used as a therapeutic for hypotension related to vagotonia type autonomic dysfunction.


Features and Benefits


This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyUBRKDAVQCKZSPO-UHFFFAOYSA-N
InChI1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥98% (HPLC)

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