ACT-462206

Descriptions

Biochem/physiol Actions

ACT-462206 is a orally active, brain penetrant, potent and selective dual orexin1/2 receptor antagonist (DORA). ACT-462206 decreases wakefulness, decreases sleep latency, and increases sleep efficacy in rats and dogs.

ACT-462206 is a proline sulphonamide with the potential to treat insomnia. On absorption, its displays asthenia, blurred vision, and fatigue as adverse events.

Packaging

5, 25 mg in glass bottle

Specifications

Colour	white to beige
Quality Level	100
InChI key	NHPQGZOBHSVTAQ-IBGZPJMESA-N
InChI	1S/C20H24N2O4S/c1-14-11-15(2)13-16(12-14)21-20(23)19-5-4-10-22(19)27(24,25)18-8-6-17(26-3)7-9-18/h6-9,11-13,19H,4-5,10H2,1-3H3,(H,21,23)/t19-/m0/s1
Manufacturer	SIGMA-ALDRICH
Solubility	DMSO: 20 mg/mL, clear
Form	powder
Assay	≥98% (HPLC)