ABIRATERONE ACETATE

ABIRATERONE ACETATE

Stock Code: 3575032
Manufacturer Part No: SML1527-25MG
Order Now for 7 day delivery
Click Add to Quote for price and delivery
Quantity: - +

Application


Abiraterone acetate has been used to study its antitumor action in 3D micro-tumour platform.


Biochem/physiol Actions


Abiraterone acetate is a prodrug of abiraterone, which is a potent, selective, and orally bioavailable inhibitor of CYP17A1 (CYP450c17), an enzyme that catalyzes two key serial reactions (17? hydroxylase and 17,20 lyase) in androgen and estrogen biosynthesis resulting in the formation of DHEA and androstenedione, which may ultimately be metabolized into testosterone. CYP17 is the key enzyme for androgen biosynthesis in both the testes and adrenals, so its inhibition should stop the production of androgens in both places. Abiraterone acetate is used for the treatment of metastatic castration-resistant prostate cancer. Abiraterone acetate possesses significant antitumor activity in post-docetaxel patients with CRPC (castration-resistant prostate cancer). It is highly essential for androgen biosynthesis in the testes, adrenal glands, and prostate tissue.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyUVIQSJCZCSLXRZ-UBUQANBQSA-N
InChI1S/C26H33NO2/c1-17(28)29-20-10-12-25(2)19(15-20)6-7-21-23-9-8-22(18-5-4-14-27-16-18)26(23,3)13-11-24(21)25/h4-6,8,14,16,20-21,23-24H,7,9-13,15H2,1-3H3/t20-,21-
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥98% (HPLC)

There are no downloads for this product.