Biochem/physiol Actions
51164 is a neuron penetrant, potent and selective positive allosteric modulator of TRPC6 channels that activates neuronal store-operated calcium entry (nSOCE) in the hippocampal neurons spines. 51164 fully rescues mushroom spines in Aß42-treated neurons. It restores long-term potentiation (LTP) deficit in 6 months old hippocampal slices from 5xFAD mouse model.
| Colour | white to beige |
|---|---|
| Manufacturer | SIGMA-ALDRICH |
| Storage Temp. | 2-8°C |
| Solubility | DMSO: 2 mg/mL, clear |
| Form | powder |
| Assay | ≥98% (HPLC) |
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