10058-F4, >=98% (HPLC), solid

10058-F4, >=98% (HPLC), solid

Stock Code: 3573375
Manufacturer Part No: F3680-5MG
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£107.95 (exc VAT) per 5MG
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Application


10058-F4 has been used:as c-Myc inhibitor to treat stromal cellsas c-Myc inhibitor to determine the effect of c-Myc inhibition on cardiac progenitor cells (CPC) growthas c-Myc inhibitor to culture T cellsto treat C4-2 cells to examine the activity of MST1 promoter luciferase reporter construct


Biochem/physiol Actions


10058-F4 is a c-Myc inhibitor that induces cell-cycle arrest and apoptosis. 10058-F4 is a cell-permeable thiazolidinone that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression. 10058-F4 inhibits tumor cell growth in a c-Myc-dependent manner both in vitro and in vivo (64 µM using c-Myc transfected Rat1a fibroblasts).


Features and Benefits


This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.


Packaging


5, 25 mg in glass bottle

Colouryellow
Quality Level100
InChI keySVXDHPADAXBMFB-JXMROGBWSA-N
InChI1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+
ManufacturerSIGMA-ALDRICH
SolubilityH2O: ﹤2 mg/mL, DMSO: >10 mg/mL
Formsolid
Assay≥98% (HPLC)

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