1-EBIO, >=98% (HPLC)
Application
1-EBIO was used to study the electrical activity modulated by Ca+2-activated K+ channels in rat central neurons. The effect of 1-EBIO on human intermediate conductance channels was studied.
Biochem/physiol Actions
1-EBIO potentiates the secretion of CFTR-mediated Cl? ion secretion by activating the basolateral KCNN4 K+ channels in native human colonic tissues. It stimulates the apical Cl? channels and Ca+2-dependent basolateral K+ channels to stimulate fluid transport in lacrimal glands.
1-EBIO is an activator of epithelial Ca2+-activated K+ channel also known as the intermediate-conductance Ca(2+)-activated K(+) channel (IK-1) or KCa3.1.
Packaging
10, 50 mg in glass bottle
| Quality Level | 100 |
|---|---|
| InChI key | CXUCKELNYMZTRT-UHFFFAOYSA-N |
| InChI | 1S/C9H10N2O/c1-2-11-8-6-4-3-5-7(8)10-9(11)12/h3-6H,2H2,1H3,(H,10,12) |
| Manufacturer | SIGMA-ALDRICH |
| Storage Temp. | room temp |
| Solubility | DMSO: ≥20 mg/mL |
| Form | powder |
| Assay | ≥98% (HPLC) |
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