(2R6R)-HYDROXYNORKETAMINE HYDROCHLORIDE

(2R6R)-HYDROXYNORKETAMINE HYDROCHLORIDE

Stock Code: 3575489
Manufacturer Part No: SML1873-5MG
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£189.43 (exc VAT) per 5MG
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Biochem/physiol Actions


(2R,6R)-Hydroxynorketamine is a ketamine metabolite that has rapid antidepressant activity without ketamine-related side effects. The NMDAR antagonist (R,S)-ketamine must be metabolized to (2S,6S;2R,6R)-hydroxynorketamine (HNK) to have antidepressant effects. The (2R,6R)-HNK enantiomer appears to be the enantiomer most responsible for antidepressant effects in a mouse study and unlike (2S,6S)-HNK, (2R,6R)-HNK caused no significant changes in locomotion or coordination. (2R,6R)-HNK does not seem to have the same addiction potential as ketamine, since mice did not self-administer pharmacologically relevant doses of (2R,6R)-HNK under the same conditions where ketamine was readily self-administered. The (2R,6R)-HNK antidepressant appears to involve activation of AMPA glutamate receptors rather than inhibition of NMDA glutamate receptors.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
ManufacturerSIGMA-ALDRICH
SolubilityH2O: 25 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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