(-)-EPOTHILONE B FROM SORANGIUM CELLULO

(-)-EPOTHILONE B FROM SORANGIUM CELLULO

Stock Code: 3573349
Manufacturer Part No: E2656-5MG
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Biochem/physiol Actions


(-)-Epothilone B is a microtubule (MT) stabilizing drug and natural macrolide antitumor from myxobacteria Sorangium cellulosum. EpoB has similar biological properties to EpoA. However, EpoB is 10-fold more potent than EpoA against P-glycoprotein-expressing multidrug resistant (MDR) cells (IC50 = 2 nM for MDR CCRF-CEM/VBL100 cells). (-)-Epothilone B is similar to paclitaxel in binding displacement, and a substitution for paclitaxel in dependent cell growth. EpoB causes cell cycle arrest (IC50 = 3.5 nM).


General description


Epothilones has antimitotic properties. It prevents microtubule depolymerization and competitively blocks paclitaxel binding to microtubules. Epothilone B is used to treat metastatic breast cancer (MBC).


Packaging


1, 5 mg in glass bottle

Colourwhite to off-white
Quality Level100
InChI keyQXRSDHAAWVKZLJ-PVYNADRNSA-N
InChI1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13
ManufacturerSIGMA-ALDRICH
Formlyophilized powder
Assay≥98% (HPLC)

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