-Butaprost, >=98% (HPLC)

-Butaprost, >=98% (HPLC)

Stock Code: 3573283
Manufacturer Part No: B6309-1MG
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£254.89 (exc VAT) per 1MG
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Application


(R)-Butaprost has been used as a prostanoid receptor (EP)-specific agonist to study its effects on protein kinase A (PKA) regulatory subunits in MCF7 cells. It may be used as EP2 agonist in Madin-Darby canine kidney and mouse cortical collecting duct (mpkCCD14) cells. It may also be used as EP2 agonist in human fetal lung fibroblasts (HFL-1) cells to test its effect on vascular endothelial growth factor (VEGF) production.


Biochem/physiol Actions


Butaprost comprises hydroxy-cyclopentanone ring and ?-chain. It aids protection in events of glutamate based N-methyl-D-aspartate receptor toxicity. Butaprost inhibits conjunctival fibrosis and lowers the intraocular pressure in post glaucoma filtration surgery. It also promotes wound healing by reducing the subconjunctival scarring Tenon?s fibroblasts. Butaprost plays a protective role in pulmonary fibrosis and aids protection against the aggregated amyloid ? (A?) peptides in Alzheimer?s disease.


(R)-Butaprost is a selective EP2 prostanoid receptor agonist.


Features and Benefits


This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.


Packaging


1, 5 mg in glass bottle

Colourlight yellow
Quality Level100
InChI keyXRISENIKJUKIHD-LHQZMKCDSA-N
InChI1S/C24H40O5/c1-3-14-24(15-9-16-24)22(27)12-8-11-19-18(20(25)17-21(19)26)10-6-4-5-7-13-23(28)29-2/h8,11,18-19,21-22,26-27H,3-7,9-10,12-17H2,1-2H3/b11-8+/t18-,19
ManufacturerSIGMA-ALDRICH
Formoil
Assay≥98% (HPLC)

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