Z-Leu-Leu-Norvalinal, >=90% (HPLC), powder

Descriptions

Amino Acid Sequence

Z-Leu-Leu-Nva

Biochem/physiol Actions

Potent inhibitor of the 20S proteasome (K_i = 21 nM) and 26S proteasome (K_i = 35 nM). Cells treated with 54 µM N-CBZ-Leu-Leu-Norvalinal showed complete block of the G1/S and metaphase transitions and delayed passage through S-phase. Induces apoptosis in Rat-1 and PC12 cells, perhaps by accumulation of stabilized p53.

Packaging

1, 5 mg in serum bottle

Specifications

Colour	white
Quality Level	100
InChI key	QEJRGURBLQWEOU-FKBYEOEOSA-N
InChI	1S/C25H39N3O5/c1-6-10-20(15-29)26-23(30)21(13-17(2)3)27-24(31)22(14-18(4)5)28-25(32)33-16-19-11-8-7-9-12-19/h7-9,11-12,15,17-18,20-22H,6,10,13-14,16H2,1-5H3,(H
Manufacturer	SIGMA-ALDRICH
Form	powder
Assay	≥90% (HPLC)