BQ-123, >=99%, lyophilized powder
Amino Acid Sequence
cyclo-Asp-Pro-Val-Leu-Trp
Application
BQ-123 has been used as a selective endothelin-A receptor antagonist to study its effects on tumor necrosis factor ? (TNF?)-induced human airway smooth muscle cells (HASMCs) proliferation. It is also used as endothelin-A receptor antagonist to study its effects on TNF?-induced granulocyte–macrophage colony-stimulating factor (GM-CSF) expression.
Biochem/physiol Actions
BQ-123 is an endothelin(Et) receptor antagonist and is exquisite for endothelin A (ETA) receptor. It is a cyclic pentapeptide.
Selective ETA endothelin receptor antagonist.
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