N-Formyl-Met-Leu-Phe, >=97% (HPLC)

N-Formyl-Met-Leu-Phe, >=97% (HPLC)

Amino Acid Sequence

NFor-Met-Leu-Phe

Application

N-Formyl-Met-Leu-Phe has been used for:creating gradients in Zigmond chamber chemotaxis assay performed on neutrophilsuse in neutrophil chemotaix assay anddetermination of the involvement of MAPK-activating protein kinase-2 (MAPKAPK-2) and/or p38, in the signaling pathway of human polymorphonuclear leukocytes (PMNs) stimulated by N-Formyl-Met-Leu-Phe.

Biochem/physiol Actions

Potent inducer of leucocyte chemotaxis and macrophage activator. Receptors that bind formylpeptides are found on phagocytic neutrophils and have recently been identified on cells of the intestinal mucosa.

N-Formyl-Met-Leu-Phe induced chemotaxis in phosphoinositide 3-kinase ? (PI3K)?-/- neutrophils, and promotes adhesion, polymerization of F-actin, Fc? receptor-mediated phagocytosis and intracellular Ca2+ release. It acts as an inflammatory agent and activates polymorphonuclear leukocytes (PMNs) without the formation of 5-hydroxyicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4). Its effects on neutrophils and the inhibition of adenylate cyclase are inhibited by pertussis toxin.

Potent chemotactic peptide. Induces a metabolic burst in macrophages accompanied by an increase in respiratory rate, secretion of lysosomal enzymes, and production of superoxide anion.

General description

N-Formyl-Met-Leu-Phe is a chemotactin peptide, which functions on polymorphonuclear leukocytes (PMN), neutrophils etc.

Packaging

5, 10 mg in glass insert

50, 100, 500 mg in glass bottle

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Code Description Quality Level InChI key InChI Manufacturer Storage Temp. Assay Price Quantity
3591196 N-Formyl-Met-Leu-Phe, >=97% (HPLC) 100 PRQROPMIIGLWRP-BZSNNMDCSA-N 1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)( SIGMA-ALDRICH −20°C ≥97% (HPLC)
£430.39 (exc VAT) per 100MG
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3591198 N-Formyl-Met-Leu-Phe, >=97% (HPLC) 100 PRQROPMIIGLWRP-BZSNNMDCSA-N 1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)( SIGMA-ALDRICH −20°C ≥97% (HPLC)
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3591199 N-Formyl-Met-Leu-Phe, >=97% (HPLC) 100 PRQROPMIIGLWRP-BZSNNMDCSA-N 1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)( SIGMA-ALDRICH −20°C ≥97% (HPLC)
£392.79 (exc VAT) per 50MG
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