6-Hydroxy-DL-DOPA, >=98% (TLC), powder
Biochem/physiol Actions
Precursor of the catecholaminergic neurotoxin, 6-hydroxydopamine; converted to 6-hydroxydopamine by L-aromatic amino acid decarboxylase.
6-Hydroxy-DL-DOPA is an inhibitor of APE1 (apurinic/apyrimidinic endonuclease) repair-function activity. APE1 is a nuclease crucial for DNA base excision repair pathway. 6-Hydroxy-DL-DOPA also blocks RAD52 (DNA repair protein) single-stranded DNA binding domain.
Caution
Hygroscopic; photosensitive
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
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