Resorufin ethyl ether,

Resorufin ethyl ether,

Application

Resorufin ethyl ether is suitable for the study of dealkylating activity of cytochrome P450 isozymes 1A1 and 1A2, where arylalkyl and alkyl isothiocyanates, and their glutathione, cysteine, and A?-acetylcysteine conjugates are used as inhibitors. It is suitable to study the ethoxyresorufin-O-deethylase (EROD) activity of cytochrome P450 activity (CYP1A1).

General description

Resorufin ethers are used as markers or substrates for different cytochrome P (CYP) isoforms. Resorufin ethyl ether is the preferred resorufin ether to be metabolized by microsomes of 3-methylcholanthrene treated animals.

Resorufin is the reduced product of resazurin, also termed as Alamar Blu. It exhibits fluorescence at longer wavelengths and is flexible for modification in its hydroxyl group.

Packaging

1, 5 mg in glass bottle

Substrates

Fluorimetric substrate for cytochrome P450 linked enzyme, CXPIA1/2

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Code Description Quality Level mp InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3591121 Resorufin ethyl ether, 200 223-225 °C (lit.) ZOSYTBPPLWBBKM-UHFFFAOYSA-N 1S/C23H14F5NO4.C14H11NO3/c24-17-18(25)20(27)22(21(28)19(17)26)33-16(30)9-29-23(31)32-10-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15;1-2-17-10-4-6-12-14(8-10)18-13- SIGMA-ALDRICH chloroform: 9.80-10.20 mg/mL, clear, orange powder ≥98% (TLC)
£129.68 (exc VAT) per 1MG
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3591122 Resorufin ethyl ether, 200 223-225 °C (lit.) ZOSYTBPPLWBBKM-UHFFFAOYSA-N 1S/C23H14F5NO4.C14H11NO3/c24-17-18(25)20(27)22(21(28)19(17)26)33-16(30)9-29-23(31)32-10-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15;1-2-17-10-4-6-12-14(8-10)18-13- SIGMA-ALDRICH chloroform: 9.80-10.20 mg/mL, clear, orange powder ≥98% (TLC)
£449.89 (exc VAT) per 5MG
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