Z-Leu-Leu-Norvalinal, >=90% (HPLC), powder

Amino Acid Sequence

Z-Leu-Leu-Nva

Biochem/physiol Actions

Potent inhibitor of the 20S proteasome (Ki = 21 nM) and 26S proteasome (Ki = 35 nM). Cells treated with 54 µM N-CBZ-Leu-Leu-Norvalinal showed complete block of the G1/S and metaphase transitions and delayed passage through S-phase. Induces apoptosis in Rat-1 and PC12 cells, perhaps by accumulation of stabilized p53.

Packaging

1, 5 mg in serum bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Form Assay Price
3589944 Z-Leu-Leu-Norvalinal, >=90% (HPLC), powder white 100 QEJRGURBLQWEOU-FKBYEOEOSA-N 1S/C25H39N3O5/c1-6-10-20(15-29)26-23(30)21(13-17(2)3)27-24(31)22(14-18(4)5)28-25(32)33-16-19-11-8-7-9-12-19/h7-9,11-12,15,17-18,20-22H,6,10,13-14,16H2,1-5H3,(H SIGMA-ALDRICH powder ≥90% (HPLC)
3589945 Z-Leu-Leu-Norvalinal, >=90% (HPLC), powder white 100 QEJRGURBLQWEOU-FKBYEOEOSA-N 1S/C25H39N3O5/c1-6-10-20(15-29)26-23(30)21(13-17(2)3)27-24(31)22(14-18(4)5)28-25(32)33-16-19-11-8-7-9-12-19/h7-9,11-12,15,17-18,20-22H,6,10,13-14,16H2,1-5H3,(H SIGMA-ALDRICH powder ≥90% (HPLC)
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