[Met5]Enkephalin acetate salt hydrate, >=95.0% (HPLC), powder

[Met5]Enkephalin acetate salt hydrate, >=95.0% (HPLC), powder

Amino Acid Sequence

Tyr-Gly-Gly-Phe-Met

Application

[Met5] Enkephalin acetate salt hydrate has been used to study the effect of mutations in opioid growth factor receptor on growth of human cancer cell line.

Biochem/physiol Actions

Opioid peptides play a crucial role in various physiological process such as pain mediation, opiate dependence and euphoria and members of this class contain aromatic residues in positions 1 and 4. [Met5] Enkephalin acts as a cytokine and is implicated in improving immune response in patients with cancer or AIDS. [Met5] Enkephalin boosts immune functions at low concentration and suppress at high concentration. ME is associated with glucose homeostasis. Increased concentration of ME is observed in plasma of type I diabetic patients.

Met-enkephalin is endogenous opioid neurotransmitter/neuromodulator with agonist activity at μ and δ opioid receptors. Enhancement of immune system function is mediated through met-enkephalin receptors on leukocytes. Met-enkephalin also functions as a growth factor on many cell types at a receptor that is distinct from the neuronal opioid receptors.

General description

[Met5] Enkephalin (ME) is an opioid pentapeptide, which acts as a neurotransmitter or neuromodulator in the central nervous system. [Met5] Enkephalin is activated on interaction with three main subtypes of receptors including ?and ? opioid receptors mediating classic opioid effects of met-Enk and ? -receptors mediating non-opioid actions of the peptide, i.e. retardation of cell growth. [Met5] Enkephalin is derived from precursor peptide pro-methionine-enkephalin in vitro consisting of H-Tyr-Gly-Gly-Phe-Met-Arg-OH amino acid sequence. The peptide activity is observed in the central nervous, neuroendocrine and immune systems.

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Code Description Colour Quality Level InChI key InChI Manufacturer Composition Form Assay Price Quantity
3591797 [Met5]Enkephalin acetate salt hydrate, >=95.0% (HPLC), powder white 200 NNACMJQGYXGHNE-DUQFDOSRSA-N 1S/C27H35N5O7S.C2H4O2.H2O/c1-40-12-11-21(27(38)39)32-26(37)22(14-17-5-3-2-4-6-17)31-24(35)16-29-23(34)15-30-25(36)20(28)13-18-7-9-19(33)10-8-18;1-2(3)4;/h2-10, SIGMA-ALDRICH acetate, 2.5-20% powder ≥95.0% (HPLC)
£647.68 (exc VAT) per 100MG
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3591798 [Met5]Enkephalin acetate salt hydrate, >=95.0% (HPLC), powder white 200 NNACMJQGYXGHNE-DUQFDOSRSA-N 1S/C27H35N5O7S.C2H4O2.H2O/c1-40-12-11-21(27(38)39)32-26(37)22(14-17-5-3-2-4-6-17)31-24(35)16-29-23(34)15-30-25(36)20(28)13-18-7-9-19(33)10-8-18;1-2(3)4;/h2-10, SIGMA-ALDRICH acetate, 2.5-20% powder ≥95.0% (HPLC)
£169.93 (exc VAT) per 10MG
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3591799 [Met5]Enkephalin acetate salt hydrate, >=95.0% (HPLC), powder white 200 NNACMJQGYXGHNE-DUQFDOSRSA-N 1S/C27H35N5O7S.C2H4O2.H2O/c1-40-12-11-21(27(38)39)32-26(37)22(14-17-5-3-2-4-6-17)31-24(35)16-29-23(34)15-30-25(36)20(28)13-18-7-9-19(33)10-8-18;1-2(3)4;/h2-10, SIGMA-ALDRICH acetate, 2.5-20% powder ≥95.0% (HPLC)
£40.67 (exc VAT) per 1MG
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3591800 [Met5]Enkephalin acetate salt hydrate, >=95.0% (HPLC), powder white 200 NNACMJQGYXGHNE-DUQFDOSRSA-N 1S/C27H35N5O7S.C2H4O2.H2O/c1-40-12-11-21(27(38)39)32-26(37)22(14-17-5-3-2-4-6-17)31-24(35)16-29-23(34)15-30-25(36)20(28)13-18-7-9-19(33)10-8-18;1-2(3)4;/h2-10, SIGMA-ALDRICH acetate, 2.5-20% powder ≥95.0% (HPLC)
£299.46 (exc VAT) per 25MG
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3591801 [Met5]Enkephalin acetate salt hydrate, >=95.0% (HPLC), powder white 200 NNACMJQGYXGHNE-DUQFDOSRSA-N 1S/C27H35N5O7S.C2H4O2.H2O/c1-40-12-11-21(27(38)39)32-26(37)22(14-17-5-3-2-4-6-17)31-24(35)16-29-23(34)15-30-25(36)20(28)13-18-7-9-19(33)10-8-18;1-2(3)4;/h2-10, SIGMA-ALDRICH acetate, 2.5-20% powder ≥95.0% (HPLC)
£96.66 (exc VAT) per 5MG
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