L-Mimosine from Koa hoale seeds, >=98%

L-Mimosine from Koa hoale seeds, >=98%

Application

L-Mimosine from Koa hoale seeds has been used to study its anti-inflammatory effect in chronic inflammatory response (potassium permanganate - induced chronic granuloma).

Biochem/physiol Actions

L-Mimosine is a plant amino acid and potential inhibitor of the cell cycle giving rise to growth arrest in G1-phase. It is an iron chelator that inhibits DNA replication in mammalian cells. L-Mimosine has been shown to promote apoptosis in xenotransplanted human pancreatic cancer. L-Mimosine stabilizes hypoxia inducible factor 1 (HIF-1) and stimulates the expression of B-cell translocation gene 2 (Btg2) and N-myc downstream regulated gene 1 (Ndrg1) at the transcriptional level, which reduce cell proliferation of prostate carcinoma cells in vitro. L-Mimosine stabilizes HIF-1 through the inhibition of prolyl hydroxylases (PHDs) which target HIF-1 through degradation. The mechanism of inhibition is likely through the chelation of Fe2+ bound to the active site of PHD which is required for enzymatic activity. Mimosine inhibits cell cycle progression via iron chelation in MDA-MB-453 human breast cancer cells. Mimosine, hinder folate metabolism in cell-specific manner.

General description

L-mimosine [?-N (3-hydroxy-4-pyridone)-?-amino propionic acid] is a non-protein amino acid and is a vital component of tropical legumes, such as Leucaena glauca and other legumes belonging to Mimosa spp. Structurally L-mimosine resembles dihydroxyphenylalanine except 3,4-dihydroxy-phenyl ring replaced by 3-hydroxy-4-pyridone ring.

Packaging

1 g in glass bottle

100, 500 mg in glass bottle

25 mg in poly bottle

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Code Description Quality Level InChI key InChI Manufacturer Assay Price Quantity
3591695 L-Mimosine from Koa hoale seeds, >=98% 200 WZNJWVWKTVETCG-YFKPBYRVSA-N 1S/C8H10N2O4/c9-5(8(13)14)3-10-2-1-6(11)7(12)4-10/h1-2,4-5,12H,3,9H2,(H,13,14)/t5-/m0/s1 SIGMA-ALDRICH ≥98%
£78.70 (exc VAT) per 100MG
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3591696 L-Mimosine from Koa hoale seeds, >=98% 200 WZNJWVWKTVETCG-YFKPBYRVSA-N 1S/C8H10N2O4/c9-5(8(13)14)3-10-2-1-6(11)7(12)4-10/h1-2,4-5,12H,3,9H2,(H,13,14)/t5-/m0/s1 SIGMA-ALDRICH ≥98%
£472.18 (exc VAT) per 1G
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3591697 L-Mimosine from Koa hoale seeds, >=98% 200 WZNJWVWKTVETCG-YFKPBYRVSA-N 1S/C8H10N2O4/c9-5(8(13)14)3-10-2-1-6(11)7(12)4-10/h1-2,4-5,12H,3,9H2,(H,13,14)/t5-/m0/s1 SIGMA-ALDRICH ≥98%
£25.77 (exc VAT) per 25MG
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3591698 L-Mimosine from Koa hoale seeds, >=98% 200 WZNJWVWKTVETCG-YFKPBYRVSA-N 1S/C8H10N2O4/c9-5(8(13)14)3-10-2-1-6(11)7(12)4-10/h1-2,4-5,12H,3,9H2,(H,13,14)/t5-/m0/s1 SIGMA-ALDRICH ≥98%
£215.89 (exc VAT) per 500MG
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