Tyr-Ile-Gly-Ser-Arg, >=97% (HPLC)

Tyr-Ile-Gly-Ser-Arg, >=97% (HPLC)

Amino Acid Sequence

Tyr-Ile-Gly-Ser-Arg

Application

Tyr-Ile-Gly-Ser-Arg (YIGSR) can be used at the interface between the conjugated polymer and the tissue for the engineering of tissue interface. The product can also be used to study the role of integrins ?1, ?6, and ?3 in promoting type II epithelial differentiation during lung maturation in the fetus.

Biochem/physiol Actions

Tyr-Ile-Gly-Ser-Arg (YIGSR) is a pentapeptide of the protein laminin that reduces the lung colony formation in mice administered with melanoma cells as well as can block the invasiveness of the cells in vitro. It inhibits the increased expression of endothelial nitric-oxide synthase in primary porcine aortic endothelial cells.

Tyr-Ile-Gly-Ser-Arg is a fragment of domain III of the laminin B1 chain . It is a major receptor binding site in laminin. It competes with laminin for the cell surface receptor. It is an inhibitor of tumor growth and metastasis.

Preparation Note

Tyr-Ile-Gly-Ser-Arg dissolves in water at 1 mg/ml to yield a clear, colorless solution.

No detailed specifications are available for this product.

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Code Description Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3593786 Tyr-Ile-Gly-Ser-Arg, >=97% (HPLC) 200 MWOGMBZGFFZBMK-LJZWMIMPSA-N 1S/C26H42N8O8/c1-3-14(2)21(34-22(38)17(27)11-15-6-8-16(36)9-7-15)24(40)31-12-20(37)32-19(13-35)23(39)33-18(25(41)42)5-4-10-30-26(28)29/h6-9,14,17-19,21,35-36H, SIGMA-ALDRICH H2O: soluble 1 mg/mL, clear, colorless powder ≥97% (HPLC)
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3593787 Tyr-Ile-Gly-Ser-Arg, >=97% (HPLC) 200 MWOGMBZGFFZBMK-LJZWMIMPSA-N 1S/C26H42N8O8/c1-3-14(2)21(34-22(38)17(27)11-15-6-8-16(36)9-7-15)24(40)31-12-20(37)32-19(13-35)23(39)33-18(25(41)42)5-4-10-30-26(28)29/h6-9,14,17-19,21,35-36H, SIGMA-ALDRICH H2O: soluble 1 mg/mL, clear, colorless powder ≥97% (HPLC)
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